Encino is a neighborhood in the San Fernando Valley region of Los Angeles, California. Encino is situated in the central portion of the southern San Fernando Valley and on the north slope of the Santa Monica Mountains. It is flanked on the north by Reseda and the Sepulveda Basin, on the east by Sherman Oaks, on the southeast by Bel-Air, on the south by Brentwood, and on the west by Tarzana.